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  • zh
  • 2 months ago
  • $2.79

Tendermint Core Blockchain Development

Developing chain applications is pretty hard work, so starting from scratch is not very pleasant. Some frameworks I tried, like Truffle , OpenZeppelin etc. was step in the right direction, but still not very easy - new programming language, a lot of restrictions (integers only, no random etc.).

Founding a real world working OSS project is a very, very good way to start. I researched for a while and this bring me to Cosmos , and most specifically to Cosmos SDK - "...A Framework for Building High Value Public Blockchains...". Great, let's start digging...

Reading the project documentation however I found something even better - Tendermint Core . An amazing project! Working horse for a lot of blockchain related OSS development projects. Let's start from the core!

  • 2 months ago
  • $350.00

Naturally occurring anti-cancer compounds - The Complete Uncensored Guide!

This is not just another run-of-the-mill article about cancer, this is the real-deal.

The main target molecules and signaling involved in the pharmacological processes include reactive oxygen species (ROS), matrix metalloproteinases (MMPs), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), signal transducer and activator of transcription and cell cycle-related proteins. Shown to induce anti-cancer activities through the disruption of mitochondrial membrane potential and blockade at G2/M phase of the cell cycle in human epidermoid carcinoma A-431 cells. In addition, induces apoptosis and autophagy through the inhibition of phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway in human NSCLC A549 cells, while it induces autophagy by reducing Akt phosphorylation and mTOR in human melanoma A375 and C8161 cells.

Decreases pro-inflammatory cytokine secretion from activated T cells, and enhances T cell-induced cytotoxicity in human esophageal adenocarcinoma OE33 and OE19 cells, so it increases the sensitivity of the cells to T cell-induced cytotoxicity. The natural killing (NK) cells can directly kill cancer cells, and can enhance the cytotoxicity effect of NK cells when NK cells are co-cultured with human breast cancer MDA-MB-231 cells, which is highly associated with signal transducer and activator of transcription 4 (STAT4) and signal transducer and activator of transcription 5 (STAT5) activation. Besides, myeloid-derived suppressor cells (MDSCs) are immune-suppressive cells which are found in most cancer patients. Decreases interleukin (IL)-6 levels in the tumor tissues and serum of Lewis lung carcinoma (LLC)-bearing mice to impair the growth of MDSCs, so targeting MDSCs is important for the treatment of lung cancer. unlock the content to download the full guide.