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  • zh
  • 29 days ago
  • $2.00

Cosmos SDK Blockchain Development

Tendermint core give you a ready to go state-machine replication engine a.k.a blockchain. Great foundation, but coding actual state machines on top of it is not so easy. And in fact it is not the job for any core to do this.

Here the Cosmos project comes. The project describes itself as "...a decentralized network of independent parallel blockchains, each powered by BFT consensus algorithms like Tendermint consensus...". They have very active OSS development - more then 40 active repositories on GitHub!

  • zh
  • 1 month ago
  • $2.79

Tendermint Core Blockchain Development

Developing chain applications is pretty hard work, so starting from scratch is not very pleasant. Some frameworks I tried, like Truffle , OpenZeppelin etc. was step in the right direction, but still not very easy - new programming language, a lot of restrictions (integers only, no random etc.).

Founding a real world working OSS project is a very, very good way to start. I researched for a while and this bring me to Cosmos , and most specifically to Cosmos SDK - "...A Framework for Building High Value Public Blockchains...". Great, let's start digging...

Reading the project documentation however I found something even better - Tendermint Core . An amazing project! Working horse for a lot of blockchain related OSS development projects. Let's start from the core!

  • 1 month ago
  • $350.00

Naturally occurring anti-cancer compounds - The Complete Uncensored Guide!

This is not just another run-of-the-mill article about cancer, this is the real-deal.

The main target molecules and signaling involved in the pharmacological processes include reactive oxygen species (ROS), matrix metalloproteinases (MMPs), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), signal transducer and activator of transcription and cell cycle-related proteins. Shown to induce anti-cancer activities through the disruption of mitochondrial membrane potential and blockade at G2/M phase of the cell cycle in human epidermoid carcinoma A-431 cells. In addition, induces apoptosis and autophagy through the inhibition of phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway in human NSCLC A549 cells, while it induces autophagy by reducing Akt phosphorylation and mTOR in human melanoma A375 and C8161 cells.

Decreases pro-inflammatory cytokine secretion from activated T cells, and enhances T cell-induced cytotoxicity in human esophageal adenocarcinoma OE33 and OE19 cells, so it increases the sensitivity of the cells to T cell-induced cytotoxicity. The natural killing (NK) cells can directly kill cancer cells, and can enhance the cytotoxicity effect of NK cells when NK cells are co-cultured with human breast cancer MDA-MB-231 cells, which is highly associated with signal transducer and activator of transcription 4 (STAT4) and signal transducer and activator of transcription 5 (STAT5) activation. Besides, myeloid-derived suppressor cells (MDSCs) are immune-suppressive cells which are found in most cancer patients. Decreases interleukin (IL)-6 levels in the tumor tissues and serum of Lewis lung carcinoma (LLC)-bearing mice to impair the growth of MDSCs, so targeting MDSCs is important for the treatment of lung cancer. unlock the content to download the full guide.